题目: A versatile model system for studying non-covalent interactions of aromatic surfaces
主讲人: Ken D. Shimizu
主持人: 张亚刚 教授
时 间: 2019年10月22日（周二），上午10点
地 点: 清水河校区研究院大楼304A
Ken D. Shimizu 教授是美国University of South Carolina 化学与生物化学系主任，1995年博士毕业于美国麻省理工学院，获得 SC ACS Chemist of the Year award, Mortar Board Excellence in Teaching Award 等奖十多项。主要研究领域为：超分子化学亚博体彩竞猜-官网、分子识别与分子印迹亚博体彩竞猜-官网、物理有机化学和材料化学。
Non-covalent interactions of aromatic surfaces are important to the function of many synthetic and biological systems. Yet, the fundamental origins and stability trends of these weak interactions are still a subject of considerable study and debate. One reason is the lack of accurate and comprehensive experimental data. To address this problem, we developed a small molecule model system that can form and accurately measure the strength of intramolecular interactions of aromatic surfaces. Due to a central N-arylimide single bond with restricted rotation, the rigid bicyclic framework is in equilibrium between folded and unfolded confirmations, which can and cannot form the intramolecular noncovalent interaction. Thus, measurement of the folded/unfolded ratio by H NMR integration provides a measure of the interaction of interest. Due to the synthetic versatility and ease of preparation, we have applied this model system to study a range of noncovalent interactions of aromatic surfaces including: face-to-face π-stacking, dispersion, OH-π, fluorine-π, heterocyclic π-stacking, and Ag-π.